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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
21.82
Human Site:
T465
Identified Species:
32
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
T465
E
V
T
E
E
E
K
T
K
E
E
K
P
E
A
Chimpanzee
Pan troglodytes
XP_519834
482
55098
T465
E
V
T
E
E
E
K
T
K
E
E
K
P
E
A
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
W474
G
S
R
R
R
S
S
W
P
E
Q
T
S
P
A
Dog
Lupus familis
XP_544435
482
55144
T465
E
V
T
E
E
E
K
T
K
E
E
K
Q
E
A
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
T465
E
V
T
E
E
E
K
T
K
E
E
K
P
E
A
Rat
Rattus norvegicus
Q4QQW4
482
55074
T465
E
V
T
E
E
E
K
T
K
E
E
K
P
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
D446
K
K
A
R
I
E
E
D
K
K
E
T
E
D
K
Chicken
Gallus gallus
P56517
480
54920
E465
K
E
E
E
K
A
K
E
E
K
A
E
P
K
G
Frog
Xenopus laevis
O42227
480
54874
D465
K
E
E
E
K
A
K
D
E
K
T
D
S
K
R
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
H420
F
Y
D
G
D
H
D
H
D
K
E
S
D
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
D463
E
T
S
S
E
I
K
D
E
K
E
K
G
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
G453
A
A
Q
F
E
S
E
G
G
E
K
R
Q
K
T
Sea Urchin
Strong. purpuratus
P56518
576
64060
S465
A
D
K
E
A
K
S
S
D
A
S
K
E
A
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
S473
P
M
A
E
D
I
G
S
S
K
Q
A
P
Q
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
V458
E
R
G
K
G
C
E
V
E
V
D
E
S
G
S
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
V426
Q
Y
A
R
D
L
H
V
E
H
D
N
E
F
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
13.3
93.3
N.A.
100
100
N.A.
20
20
13.3
6.6
N.A.
33.3
N.A.
13.3
13.3
P-Site Similarity:
100
100
20
93.3
N.A.
100
100
N.A.
46.6
60
46.6
20
N.A.
60
N.A.
40
26.6
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
20
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
60
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
7
19
0
7
13
0
0
0
7
7
7
0
7
44
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
19
0
7
19
13
0
13
7
7
13
0
% D
% Glu:
44
13
13
57
44
38
19
7
32
44
50
13
19
32
7
% E
% Phe:
7
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
7
0
7
7
7
0
7
7
7
0
0
0
7
7
13
% G
% His:
0
0
0
0
0
7
7
7
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
13
0
0
0
0
0
0
0
0
0
% I
% Lys:
19
7
7
7
13
7
50
0
38
38
7
44
0
19
13
% K
% Leu:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
7
0
0
0
38
7
0
% P
% Gln:
7
0
7
0
0
0
0
0
0
0
13
0
13
7
0
% Q
% Arg:
0
7
7
19
7
0
0
0
0
0
0
7
0
0
7
% R
% Ser:
0
7
7
7
0
13
13
13
7
0
7
7
19
0
7
% S
% Thr:
0
7
32
0
0
0
0
32
0
0
7
13
0
0
7
% T
% Val:
0
32
0
0
0
0
0
13
0
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _